Manganese testing should be done with both blood and urine samples to evaluate for toxicity or deficiency. Toxic levels may occur from steel or chemical industry exposure. Manganese is present in the coloring agents for glass, soap, paints, varnish, enamel and in linoleum. Industrial manganese is used in the manufacturing of chlorine gas and lead free gasoline. Industrial manganese poisoning has been recognized since 1837. Areas where water supplies are contaminated by manganese have been found to have an increased incidence in psychiatric and neurological diseases. In those areas, manganese testing is also done to evaluate individuals experiencing health problems such as epilepsy, liver disease, hepatitis, jaundice, renal dialysis and unexplained gastrointestinal distress. Manganese deficiency may affect pituitary-thyroid axis function. Normalization of plasma levels may not reverse neurological damage.
Test Preparation For Optimal Results:
If possible, have the lab collected early in the morning or shortly after waking. For comparison purposes, have subsequent labs collected close to the same time.
Disclaimer: A health care provider should evaluate a significant deviation from normal ranges.