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  • Amino Acids Urine Test

    The Amino Acids Urine Test offers important clinical data on metabolic, nutritional, and neurological disorders. The test analyzes 40 amino acids and provides a detailed explanation of the possible causes and consequences of detected abnormalities, along with nutritional information. Amino acid imbalances are frequently underlying factors in disorders such as ADD, depression, Tourette syndrome, tic disorder, OCD, seizures and others. 

    Amino Acid Testing may be useful for the following conditions
    • AD(H)D
    • Autism Spectrum
    • Bipolar Disorder
    • Chemical Exposure
    • Chronic Fatigue
    • Depression
    • Down Syndrome
    • Eating Disorders
    • Fibromyalgia
    • Schizophrenia
    • Seizure Disorders
    • Tourette Syndrome & Tics
    Potential Benefits of Amino Acid Testing
    • Clarification of health challenges suggested by other testing
    • Indications for modifying diet
    This Test Includes
    1. Essential/Conditionally indispensible amino acids
    2. Nonessential amino acids
    3. Gastrointestinal markers
    4. Magnesium-dependent markers
    5. B6, B12 & Folate-dependent markers
    6. Detoxification Markers
    7. Neurological markers
    Analyte List
    • Alanine
    • Beta-alanine
    • Alpha-aminoadipate
    • Alpha-aminobutyrate
    • Gamma-aminobutyrate
    • Beta-aminobutyrate
    • Ammonia
    • Anserine
    • Arginine
    • Asparagine
    • Aspartate
    • Carnosine
    • Citrulline
    • Creatinine
    • Cystathionine
    • Cysteine
    • Cystine
    • Ethanolamine
    • Glycine
    • Glutamate
    • Glutamine
    • Histidine
    • Homocysteine
    • Hydroxyproline
    • Isoleucine
    • Leucine
    • Lysine
    • Methionine Sulfoxide
    • Methionine
    • 1-Methylhistidine
    • 3-Methylhistidine
    • Ornithine
    • Phenylalanine
    • Phosphoethanolamine
    • Phosphoserine
    • Proline
    • Sarcosine
    • Serine
    • Taurine
    • Threonine
    • Tryptophan
    • Tyrosine
    • Valine
    • Urea
    Specimen Requirements

    25 mL of first morning urine before food or drink is required.
    The 24 hour urine collection requires that the consumer collect every urine specimen over a 24 hour period.

    Kit Instructions

    For urine instructions please click here.

    Test code: 
    Amino Acids Urine Test
  • Array 10 - Cyrex Laboratories

    The Array 10 evaluates immune reactivity to 180 foods in raw and cooked or modified forms, food enzymes, lectins and artificial food additives, including meat glue, colorings and gums. Some individuals may react to a raw food, but not the cooked form—or vice versa, and Array 10 is the only food immune reactivity test on the market that assesses foods in both their raw and cooked or modified forms. Array 10 is recommended for individuals with unexplained symptoms whether gastrointestinal, neurological, dermatological or behavioral in nature, or are suspected of having increased intestinal permeability—the gateway for environmentally-induced autoimmune disorders.

    Multiple Food Immune Reactivity Screen

    Cyrex Test Instructions:
    1. This is a Serum (blood) test.
    2. Cyrex Laboratories Blood Draw Instructions will be mailed with a Test Requisition and specimen collection kit upon receipt of payment by MyLabsforLife.
    3. Fasting not required, but please abstain from consuming overly fatty foods prior to blood draw to avoid sample rejection.
    4. Corticosteroid use and immunosuppressant drugs affect antibody production and therefore may impact test results. Please consult with your healthcare provider prior to testing if taking these medications.
    5. Please note: Cyrex Laboratories cannot accept samples from NY.

    Cyrex Laboratories Blood Draw Instructions: 
    1. Specimen collection services may be available to you at no additional charge through the Cyrex Laboratories network of contracted draw centers.
    2. This service is not available to minors under the age of 16 and is not guaranteed in all geographical areas.

    Please note that Cyrex cannot accept samples from NY.

    1. Visit www.Cyrexlabs.com and click on the blue “Schedule Blood Draw” link on the right hand side of the screen under “Patients.”
    2. Enter your Requisition ID and Confirmation Code, located at the top right hand side of the Cyrex Test Requisition Form.
    3. Click on the red “Payment and Scheduling” button. 

    Locate Contracted Draw Centers and Generate Blood Draw Authorization Form (NOT AVAILABLE IN NY)
    1. To locate the nearest contracted draw center and generate a Blood Draw Authorization form, enter a zip code if the pre-entered code is incorrect, and click on the red “Search” button. 
    2. Select a date (Monday through Friday) from the calendar provided. 
    3. Select the red “Schedule” button next to the draw center of your choice.
    4. Review your selected date and draw center location, if correct click the red “Schedule”  button at the top or bottom of the screen or     make the appropriate changes and then click “Schedule.” 
    5. Click on the “Print” button (orange printer) at the top of the screen to print the Blood Draw Authorization form. You must bring this   form with you to the appointment.
    6. Proceed to the selected blood draw center at the chosen date to complete the blood draw.

    Cyrex-contracted draw centers require the following items to perform the draw:

    1. Blood Draw Authorization form
    2. Test Requisition provided by MyLabsforLife
    3. Specimen collection kit provided by MyLabsforLife.
    4. Please ensure that you have all three items when arriving at the draw center.

    Additional Charge Option: Home Health Services (HHS) Mobile Phlebotomist (NOT AVAILABLE IN NY)
    1. If there are no contracted facilities near you, Home Health Services may be available in your area. Click on the blue “Click Here” link on the Schedule Blood Draw page.
    2. Add any Comments/Special Needs you may have, in the box provided. Please enter the best number to reach you for scheduling and your physical address
    3. The fee for Home Health Services is $44.50. Clients in remote areas may incur additional fees. To make payment for this service, enter your credit card information and click on the red “Submit” button.
    4. At this point, the Home Health Services request has been generated. You will receive a call from Cyrex Labs to confirm your address, phone number and ensure you have all required materials for the home visit.
    5. Be sure to have all required items at the time of the appointment.

    Required items for Home Health Services are:

    1. Test Requisition form (provided by MyLabsforLife)
    2. Specimen Collection Kit (provided by MyLabsforLIfe)
    3. UPS Shipping Label included with the collection kit.

    If you experience difficulty scheduling your blood draw online or have special circumstances, Cyrex Phlebotomy Services is available to assist you Mon.- Fri. 8am-5pm. Please call toll free 877-772-9739.

    1. Samples will be processed within 14 business days receipt at the laboratory.
    2. A copy of your test results will be mailed to you from MyLabsForLife.

    Your health care provider should evaluate a deviation from normal ranges.

    Test code: 
    Array 10 - Cyrex Laboraties
  • Comprehensive Stool Analysis

    Comprehensive Stool Analysis

    The Comprehensive Stool Analysis detects the presence of pathogenic microorganisms such as yeast, parasites, and bacteria that contribute to chronic illness and neurological dysfunction. It provides helpful information about prescription and natural products effective against specific strains detected in the sample. The test also evaluates beneficial bacteria levels, intestinal immune function, overall intestinal health, and inflammation markers.

    Many chronic disorders come from digestive problems and inadequate nutrient absorption. Proper gastrointestinal function is needed to eliminate toxic substances, pathogenic microbes, and undigested food particles from the body to prevent health problems. Nutrients require a specific internal environment to be properly digested and transported throughout the body.

    Abnormal intestinal microorganisms in the GI tract are widely known to cause disease. Research shows a relationship between the GI tract and the neurological, hepatic, and immune systems. For example, excessive yeast produces toxic substances that can pass through the blood-brain barrier and alter neurological functioning causing “brain fog,” behavior problems, and learning difficulties. 

    The Comprehensive Stool Analysis Includes:

    • Parameters for digestion & absorption
    • Cultures for bacteria and yeast
    • Parasite testing
    • Sensitivity panels
    • Inflammatory markers
    • Stool metabolic markers
    • Infectious pathogens

    Benefits of the Comprehensive Stool Analysis:
    • The amount of beneficial bacteria in the GI tract is determined
    • The digestive parameters aid in the diagnosis of intestinal dysfunction without invasive procedures
    • Inflammation and immune markers will aid in appropriate treatments
    • Many different pathogens have the potential to be isolated and identified
    Specimen Requirements

    Sample must be collected on two separate days (at least 12 hours apart). The specimen must be received within 10 days of the first collection. The patient must discontinue digestive enzymes, antacids, iron supplements, vitamin C over 250 mg, aspirin, anti-inflammatories, and large amounts of meat 48 hours prior to the collection of the specimen.

    Test Results: 
    Will be processed in 7-10 days after the sample is received.
    A copy of your test results will be mailed to you from MyLabsForLife

    Test code: 
    Comprehensive Stool Analysis
  • Comprehensive Stool Analysis with Parasitology x3 (Doctor’s Data)

    The Comprehensive Stool Analysis with Parasitology x 3 is used to objectively evaluate the status of beneficial and imbalanced commensal bacteria, pathogenic bacteria, yeast/fungus and parasites.

    Test Description:
    Gastrointestinal complaints are among the most common in medical care. This comprehensive profile helps pinpoint the causes of gastrointestinal symptoms and chronic systemic conditions, and measures key markers of digestion, absorption and inflammation. Using growth-based culture, the standard of practice in clinical microbiology, as well as sensitive biochemical assays and microscopy, this thorough profile evaluates the status of beneficial and pathogenic microorganisms including aerobic and anaerobic bacteria, yeast and parasites. Antimicrobial susceptibility testing to prescriptive and natural agents is also performed for appropriate bacterial and fungal species at no additional charge. Parasitology testing can include one-, two- or three-day collection, based on practitioner preference.

    Detailed Information:
    The Comprehensive Stool Analysis with Parasitology x 3 is an invaluable non-invasive diagnostic assessment that permits practitioners to objectively evaluate the status of beneficial and imbalanced commensal bacteria, pathogenic bacteria, yeast/fungus and parasites. Precise identification of pathogenic species and susceptibility testing greatly facilitates selection of the most appropriate pharmaceutical or natural treatment agents.

    Important information regarding the efficiency of digestion and absorption can be gleaned from the measurement of the fecal levels of elastase (pancreatic exocrine sufficiency), fat, muscle and vegetable fibers, and carbohydrates. Inflammation can significantly increase intestinal permeability and compromise assimilation of nutrients. The extent of inflammation, whether caused by pathogens or inflammatory bowel disease (IBD), can be assessed and monitored by examination of the levels of biomarkers such as lysozyme, lactoferrin, white blood cells and mucus. These markers can be used to differentiate between inflammation associated with potentially life-threatening inflammatory bowel disease (IBD), which requires lifelong treatment, and less severe inflammation that can be associated with irritable bowel syndrome (IBS) which is frequently due to the presence of enteroinvasive pathogens. Lactoferrin is only markedly elevated prior to and during the active phases of IBD, but not with IBS. Monitoring fecal lactoferrin levels in patients with IBD can therefore facilitate timely treatment of IBD, and the test can be ordered separately. Since the vast majority of secretory IgA (sIgA) is normally present in the GI tract, where it prevents binding of pathogens and antigens to the mucosal membrane, it is essential to know the status of sIgA in the gut. sIgA is the only bona fide marker of humoral immune status in the GI tract.

    Cornerstones of good health include proper digestion of food, assimilation of nutrients, exclusion of pathogens and timely elimination of waste. To obtain benefits from food that is consumed, nutrients must be appropriately digested and then efficiently absorbed into portal circulation. Microbes, larger-sized particles of fiber, and undigested foodstuffs should remain within the intestinal lumen. Poor digestion and malabsorption of vital nutrients can contribute to degenerative diseases, compromised immune status and nutritional deficiencies. Impairment of the highly specific nutrient uptake processes, or compromised GI barrier function, as in "leaky gut syndrome," can result from a number of causes including:

    • Low gastric acid production
    • Chronic maldigestion
    • Food allergen impact on bowel absorptive surfaces
    • Bacterial overgrowth or imbalances (dysbiosis)
    • Pathogenic bacteria, yeast or parasites and related toxic irritants
    • The use of NSAIDs and antibiotics

    Impairment of intestinal functions can contribute to the development of food allergies, systemic illnesses, autoimmune disease, and toxic overload from substances that are usually kept in the confines of the bowel for elimination. Efficient remediation of GI dysfunctions incorporates a comprehensive guided approach that should include consideration of elimination of pathogens and exposure to irritants, supplementation of hydrochloric acid, pancreatic enzymes and pre- and probiotics, and repair of the mucosal barrier.

    Sample Result.

    Test Preparation for Optimal Results:
    See Collection Information

    Test Results:
    8-14 business days one the lab has received the test kit.

    Your health care provider should evaluate a deviation from normal ranges.

    Test code: 
    Comprehensive Stool Analysis with Parasitology x3
  • Gluten and Casein Peptide Test

    Gluten / Casein Peptides Test

    The Gluten/Casein Peptides Test can determine the inability to digest wheat, rye, barley, and milk. These undigested proteins, called peptides, are associated with gastrointestinal, neurological, and neuro-developmental disorders.

    Urinary peptides are incompletely broken down pieces of protein. The peptides from gluten and casein can react with opiate receptors in the brain, thus mimicking the effects of opiate drugs like heroin and morphine. These compounds, called neuropeptides, have been shown to react with areas of the brain's temporal lobes that are involved in speech and auditory integration. Neuropeptides also decrease the ability to feel pain and effect cognitive function.

    Most people who have food allergies to milk and wheat also have problems with peptides from these foods interacting with their brain and causing an opiate-like effect. However, some individuals may not show a food allergy to milk or wheat, but have the peptide problem and vice versa. Because of this, we recommend the Gluten/Casein Peptides Test be taken in addition to our food allergy testing.

    Why are Peptides Important?

    The peptides from gluten and casein are important because they react with opiate receptors in the brain, thus mimicking the effects of opiate drugs like heroin and morphine. These compounds have been shown to react with the brain's temporal lobes that are involved in speech and auditory integration.

    Children with autism frequently seem addicted to wheat and dairy products. Presumably, people with autism and schizophrenia incompletely digest wheat and dairy products. These incompletely digested peptides are then absorbed into the body and bind to opiate receptors, altering behavior and other physiological reactions.

    Specimen Requirements

    10 mL of first morning urine before food and drink is preferred. The patient must discontinue soy proteins one week prior to collection of specimen (soy bean oil and soy lecithin are considered acceptable).

    Test code: 
    Gluten and Casein Peptide Test
  • Glyphosate

    Glyphosate General:
    Glyphosate is the world’s most widely produced herbicide and is the primary toxic chemical in Roundup™, as well as in many other herbicides. In addition, it is a broad-spectrum herbicide that is used in more than 700 different products from agriculture and forestry to home use. Glyphosate was introduced in the 1970s to kill weeds by targeting the enzymes that produce the amino acids tyrosine, tryptophan, and phenylalanine. The enzymes of many bacteria are also susceptible to inhibition by this chemical, thus altering the flora of many animals. Usage of glyphosate has since amplified, after the introduction of genetically modified (GMO) glyphosate-resistant crops that can grow well in the presence of this chemical in soil. In addition, toxicity of the surfactant commonly mixed with glyphosate, polyoxyethyleneamine (POEA), is greater than the toxicity of glyphosate alone (1). In addition, in 2014 Enlist Duo™, a herbicide product which contains a 2,4-dichlorophenoxyacetic acid (2,4-D) salt and glyphosate, was approved for use in Canada and the U.S. for use on genetically modified soybeans and genetically modified maize, both of which were modified to be resistant to both 2,4-D and glyphosate. 2,4-D has many toxic effects of its own and can be measured in the GPL-TOX test.

    Glyphosate and Autism:
    Recent studies have discovered glyphosate exposure to be a cause of many chronic health problems. It can enter the body by direct absorption through the skin, by eating foods treated with glyphosate, or by drinking water contaminated with glyphosate. A recent study (2) stated that a coherent body of evidence indicates that glyphosate could be toxic below the regulatory lowest observed adverse effect level for chronic toxic effects, and that it has teratogenic, tumorigenic and hepatorenal effects that can be explained by endocrine disruption and oxidative stress, causing metabolic alterations, depending on dose and exposure time. The World Health Organization International Agency for Research on Cancer published a summary in March 2015 that classified glyphosate as a probable carcinogen in humans (3). Possible cancers linked to glyphosate exposure include non-Hodgkin lymphoma, renal tubule carcinoma, pancreatic islet-cell adenoma, and skin tumors. Studies have also indicated that glyphosate disrupts the microbiome in the intestine, causing a decrease in the ratio of beneficial to harmful bacteria (4). Thus, highly pathogenic bacteria such as Salmonella entritidis, Salmonellagallinarum, Salmonella typhimurium, Clostridium perfringens, and Clostridium botulinum are highly resistant to glyphosate but most beneficial bacteria such as Enterococcus faecalis, Enterococcus faecium, Bacillus badius, Bifidobacterium adolescentis, and Lactobacillus spp. were found to be moderately to highly susceptible. The relationship between the microbiome of the intestine and overall human health is still unclear, but current research indicates that disruption of the microbiome could cause diseases such as metabolic disorder, diabetes, depression, autism, cardiovascular disease, and autoimmune disease.

    Treatment of glyphosate toxicity should be centered on determining the route of introduction and avoiding future exposure. Eating non-GMO (genetically modified organism) foods and drinking reverse osmosis water are two of the best ways to avoid glyphosate. A recent study showed that people eating organic food had considerably lower concentrations of glyphosate in the urine (2). Drinking extra water may also be beneficial since glyphosate is water soluble. More than 90% of corn and soy used are now of the GMO type. In addition, non-GMO wheat is commonly treated with glyphosate as a drying procedure. Glyphosate is somewhat volatile and a high percentage of rain samples contained glyphosate (2).

    Another study found that glyphosate accumulated in bones. Considering the strong chelating ability of glyphosate for calcium, accumulation in bones is not surprising. Other results showed that glyphosate is detectable in intestine, liver, muscle, spleen and kidney tissue (5). A 54-year-old man who accidentally sprayed himself with glyphosate developed disseminated skin lesions six hours after the accident (6). One month later, he developed a symmetrical parkinsonian syndrome.

    The chelating ability of glyphosate also extends to toxic metals (7). The high incidence of kidney disease of unknown etiology (renal tubular nephropathy) has reached epidemic proportions among young male farm workers in sub-regions of the Pacific coasts of the Central American countries of El Salvador, Nicaragua, Costa Rica, India, and Sri Lanka (8). The researchers propose that glyphosate forms stable chelates with a variety of toxic metals that are then ingested in the food and water or in the case of rice paddy workers, may be absorbed through the skin. These glyphosate-heavy metal chelates reach the kidney where the toxic metals damage the kidney. These authors propose that these chelates accumulate in hard water and clay soils and persist for years, compared to much shorter periods of persistence for non-chelated glyphosate. Furthermore, these chelates may not be detected by common analytical chemistry methods which can only detect free glyphosate, thus dramatically reducing estimates of glyphosate persistence in the environment when metals are high (for example, in clay soil or hard water).

    High correlations exist between glyphosate usage and numerous chronic illnesses, including autism, which is shown in the figure on the first page (9). Other disease incidences with high correlations include hypertension, stroke, diabetes , obesity, lipoprotein metabolism disorder , Alzheimer’s, senile dementia, Parkinson’s, multiple sclerosis, inflammatory bowel disease, intestinal infections, end stage renal disease, acute kidney failure, cancers of the thyroid, liver, bladder, pancreas, kidney, and myeloid leukemia (9). Correlations are not causations, yet they raise concern over the use of a chemical to which all life on earth appears to be exposed.

    Specimen Requirements:
    Urine: 10 mL of first morning urine before food and drink is preferred. The patient must discontinue soy proteins one week prior to collection of specimen (soy bean oil and soy lecithin are considered acceptable).

    Test code: 
  • GPL-TOX: Toxic Non-Metal Chemical Profile General

    Every day, we are exposed to hundreds of toxic chemicals through products like pharmaceuticals, pesticides, packaged foods, household products, and environmental pollution. As we have become more exposed to chemical-laden products and to toxic chemicals in food, air, and water, we have been confronted with an accelerating rate of chronic illnesses like cancer, heart disease, chronic fatigue syndrome, chemical sensitivity, autism spectrum disorders, ADD/AD(H)D, autoimmune disorders, Parkinson’s disease, and Alzheimer’s disease.

    Because exposure to environmental pollutants has been linked to many chronic diseases, The Great Plains Laboratory has created GPL-TOX, a toxic non-metal chemical profile that screens for the presence of 172 different toxic chemicals including organophosphate pesticides, phthalates, benzene, xylene, vinyl chloride, pyrethroid insecticides, acrylamide, perchlorate, diphenyl phosphate, ethylene oxide, acrylonitrile, and more. This profile also includes Tiglyglycine (TG), a marker for mitochondrial disorders resulting from mutations of mitochondrial DNA. These mutations can be caused by exposure to toxic chemicals, infections, inflammation, and nutritional deficiencies.

    Advantages of the GPL-TOX Profile:

    • GPL-TOX screens for 172 different environmental pollutants using 18 different metabolites, all from a single urine sample.
    • GPL-TOX uses the power of advanced mass spectrometry (MS/MS), which is necessary to detect lower levels of certain genetic, mitochondrial, and toxic chemical markers that conventional mass spectrometry often misses.
    • GPL-TOX also includes Tiglylglycine, a marker for mitochondrial damage, which is often seen in chronic toxic chemical exposure.
    • GPL-TOX pairs perfectly with our Organic Acids Test (OAT) and our Glyphosate Test in the Enviro-TOX Panel. This panel offers you comprehensive testing to assess exposure to common environmental toxins and the damage that can be caused by this exposure, all at a great value, and all from one urine sample.

    William Shaw, Ph.D., Director of The Great Plains Laboratory is board-certified in both clinical chemistry and toxicology by the American Board of Clinical Chemistry.

    Envioronmental Pollutants Tested by GPL-TOX:
    Perhaps the most widespread group of toxic chemicals found in our environment. Phthalates are commonly found in after shave lotions, aspirin, cosmetics, detergents, foods microwaved with plastic covers, oral pharmaceutical drugs, intravenous products prepared in plastic bags, hair sprays, insecticides, insect repellents, nail polish, nail polish remover, skin care products, adhesives, explosives, lacquer, janitorial products, perfumes, paper coatings, printing inks, safety glass, and varnishes. Phthalates have been implicated in reproductive damage, depressed leukocyte function, and cancer. Phthalates have also been found to impede blood coagulation, lower testosterone, and alter sexual development in children. Low levels of phthalates can feminize the male brain of the fetus, while high levels can hyper-masculinize the developing male brain.

    Vinyl Chloride
    Vinyl chloride is an intermediate in the synthesis of several commercial chemicals, including polyvinyl chloride (PVC). Exposure to vinyl chloride may cause central nervous system depression, nausea, headache, dizziness, liver damage, degenerative bone changes, thrombocytopenia, enlargement of the spleen, and death.

    Benzene is an organic solvent that is widespread in the environment. Benzene is a by-product of all sources of combustion, including cigarette smoke, and is released by outgassing from synthetic materials, and is a pollutant released by numerous industrial processes. Benzene is an extremely toxic chemical that is mutagenic and carcinogenic. High exposures to benzene cause symptoms of nausea, vomiting, dizziness, lack of coordination, central nervous system depression, and death. It can also cause hematological abnormalities.

    Pyrethrins are widely used as insecticides. Exposure during pregnancy doubles the likelihood of autism. Pyrethrins may affect neurological development, disrupt hormones, induce cancer, and suppress the immune system.

    Xylenes (dimethylbenzenes) are solvents found not only in common products such as paints, lacquers, pesticides, cleaning fluids, fuel and exhaust fumes, but also in perfumes and insect repellents. Xylenes are oxidized in the liver and bound to glycine before eliminated in urine. High xylene levels may be due to the use of certain perfumes and insect repellents. High exposures to xylene create an increase in oxidative stress, causing symptoms such as nausea, vomiting, dizziness, central nervous system depression, and death. Occupational exposure is often found in pathology laboratories where xylene is used for tissue processing.

    Styrene is used in the manufacturing of plastics, in building materials, and is found in car exhaust fumes. Polystyrene and its copolymers are widely used as food-packaging materials. The ability of styrene monomer to leach from polystyrene packaging to food has been reported. Occupational exposure due to inhalation of large amounts of styrene adversely impacts the central nervous system, causes concentration problems, muscle weakness, tiredness and nausea, and irritates the mucous membranes of the eyes, nose, and throat.

    Organophosphates are one of the most toxic groups of substances used throughout the world. They are often used as biochemical weapons and terrorist agents, but are most commonly used in pesticide formulations. Organophospates are inhibitors of cholinesterase enzymes, leading to overstimulation of nerve cells, causing sweating, salivation, diarrhea, abnormal behavior, including aggression and depression. Children exposed to organophosphates have more than twice the risk of developing pervasive developmental disorder (PDD), an autism spectrum disorder. A study done in the San Francisco Bay area found that in California agricultural areas, children born to mothers living within 500 meters of fields where organochlorine pesticides were used were more than 6 times more likely to develop autism than children whose mothers did not live near such fields. ASD risk increased with the poundage of organochlorines applied and decreased with distance from field sites. Maternal organophosphate exposure has been associated with various adverse outcomes including having shorter pregnancies and children with impaired reflexes.

    MTBE and ETBE
    MTBE and ETBE are gasoline additives used to improve octane ratings. Exposure to these compounds is most likely due to groundwater contamination, and inhalation or skin exposure to gasoline or its vapors and exhaust fumes. MTBE has been demonstrated to cause hepatic, kidney, and central nervous system toxicity, peripheral neurotoxicity, and cancer in animals. Since the metabolites of these compounds are the same, ETBE may be similarly toxic.

    2, 4-Dicholorophenoxyacetic (2,4-D)
    A very common herbicide that was a part of Agent Orange, used by the United States during the Vietnam War to increase visibility for war planes, by destroying plant undergrowth and crops. It is most commonly used in agriculture on genetically modified foods, and as a weed killer for lawns. Exposure to 2, 4-D via skin or oral ingestion is associated with neuritis, weakness, nausea, abdominal pain, headache, dizziness, peripheral neuropathy, stupor, seizures, brain damage, and impaired reflexes. 2, 4-D is a known endocrine disruptor, and can block hormone distribution and cause glandular breakdown.

    Diphenyl Phosphate
    This is a metabolite of the organophosphate flame retardant triphenyl phosphate (TPHP), which is used in plastics, electronic equipment, nail polish, and resins. TPHP can cause endocrine disruption. Studies have also linked TPHP to reproductive and developmental problems.

    Acrylamide can polymerize to form polyacrylamide. Polyacrylamide is used in many industrial processes such as plastics, food packaging, cosmetics, nail polish, dyes, and treatment of drinking water. Food and cigarette smoke are also two major sources of exposure. Acrylamide has been found in foods like potato chips, French fries, and many others such as asparagus, potatoes, legumes, nuts, seeds, beef, eggs, and fish. Asparagine, which is found in these foods can produce acrylamide when cooked at high temperature in the presence of sugars. High levels of acrylamide can elevate a patient’s risk of cancer. In addition, acrylamide is known to cause neurological damage.

    This chemical is used in the production of rocket fuel, missiles, fireworks, flares, explosives, fertilizers, and bleach. Studies show that perchlorate is often found in water supplies. Many food sources are also contaminated with perchlorate. Perchlorate can disrupt the thyroid’s ability to produce hormones. The EPA has also labeled perchlorate a likely human carcinogen. Patients that are high in perchlorate can use a reverse osmosis water treatment system to remove the chemical from their water supply.

    1,3 Butadiene
    This is a chemical made from the processing of petroleum. It is often a colorless gas with a mild gasoline-like odor. Most of this chemical is used in the production of synthetic rubber. 1,3 Butadiene is a known carcinogen and has been linked to increased risk of cardiovascular disease. Individuals that come into contact with rubber, such as car tires, could absorb 1,3 Butadiene through the skin. The increased use of old tires in the production of crumb rubber playgrounds and athletic fields is quite troubling because children and athletes may be exposed to toxic chemicals this way.

    Propylene Oxide
    This chemical is used in the production of plastics and is used as a fumigant. Propylene oxide is used to make polyester resins for textile and construction industries. It is also used in the preparation of lubricants, surfactants, and oil demulsifiers. It has also been used as a food additive, an herbicide, a microbicide, an insecticide, a fungicide, and a miticide. Propylene oxide is a probable human carcinogen.

    1-Bromopropane (1-BP)
    1-Bromopropane is an organic solvent used for metal cleaning, foam gluing, and dry cleaning. Studies have shown that 1-BP is a neurotoxin as well as a reproductive toxin. Research indicates that exposure to 1-BP can cause sensory and motor deficits. Chronic exposure can lead to decreased cognitive function and impairment of the central nervous system. Acute exposure can lead to headaches.

    Ethylene Oxide
    Ethylene oxide is used in many different industries including agrochemicals detergents, pharmaceuticals, and personal care products. Ethylene oxide is also used as a sterilizing agent on rubber, plastics, and electronics. Chronic exposure to ethylene oxide has been determined to be mutagenic to humans. Multiple agencies have reported it as a carcinogen. Studies of people exposed to ethylene oxide show an increased incidence of breast cancer and leukemia. Caution is needed with ethylene oxide because it is odorless at toxic levels.

    Acrylonitrile is a colorless liquid with a pungent odor. It is used in the production of acrylic fibers, resins, and rubber. Use of any of these products could lead to exposure to acrylonitrile. Smoking tobacco and cigarettes is another potential exposure. Exposure to acrylonitrile can lead to headaches, nausea, dizziness, fatigue, and chest pains. The European Union has classified acrylonitrile as a carcinogen.

    GPL-TOX is Recommended for The Following Disorders:

    • Alzheimer's Disease
    • Amyotrophic Lacteroclerosis (ALS)
    • Anorexia Nervosa
    • Anxiety Disorder
    • Apraxia
    • Arthritis
    • Asthma
    • Attention deficit (ADD)
    • Attention deficit with hyperactivity (ADHD)
    • Autism
    • Autoimmune disorders
    • Bipolar disorder
    • Cancer
    • Cerebral palsy
    • Chronic fatigue syndrome
    • Crohn's disease
    • Depression
    • Developmental disorder
    • Down Syndrome
    • Epilepsy
    • Failure to thrive
    • Fibromyalgia
    • Genetic diseases
    • Irritable bowel syndrome
    • Learning disability
    • Mitochondria disorder
    • Multiple sclerosis
    • Obsessive compulsive disorder (OCD)
    • Occupational exposures
    • Parkinson's disease
    • Peripheral neuropathy
    • Schizophrenia
    • Seizure disorders
    • Systemic lupus erythematosus
    • Tic disorders
    • Tourette syndrome
    • Ulcerative colitis

    Mitochondrial Disorders:
    The GPL-TOX profile tests for Tiglyglycine (TG), one of the most specific markers for mitochondrial disorders resulting from mutations of mitochondrial DNA. These mutations can result from exposure to toxic chemicals, infections, inflammation, and nutritional deficiencies. Mitochondria are important in all cells in the body, but are especially important to organs that utilize large amounts of energy, such as the muscles, heart, and brain. The mitochondria also have several other important functions in the cell, including steroid synthesis, calcium regulation, free radical production, and the induction of apoptosis or programmed cell death, all of which are involved in the pathogenesis of numerous disorders. The marker used in the GPL-TOX profile indicates mitochondrial dysfunction by monitoring a metabolite that is elevated in mitochondrial deficiency of cofactors such as NAD+, flavin-containing coenzymes, and Coenzyme Q10. Disorders associated with mitochondrial dysfunction include autism, Parkinson's disease, and cancer.

    Metabolites of Pollutants Tested by GPL-TOX:
    2-Methylhippuric Acid (2MHA), 3-Methylhippuric Acid (3MHA), 4-Methylhippuric Acid (4MHA)
    These are metabolites of xylenes, solvents found in paints, lacquers, cleaning agents, pesticides, and gasoline. Exposure to xylenes generates methylhippuric acid isomers. Avoid/reduce exposure to these substances.

    N-acetyl phenyl cysteine (NAP)
    NAP is a metabolite of benzene. Benzene is a solvent that is widespread in the environment. It is found in cigarette smoke and gasoline, and is a byproduct of all types of combustion, including motor vehicle exhaust. Treatment consists of removing sources of exposure.

    Phenylglyoxylic Acid (PGO)
    Exposure to environmental styrene may slightly increase phenylglyoxylic and mandelic acid. Reduce exposure by eliminating the use of plastic and styrofoam containers for cooking, reheating, eating or drinking. Elimination of styrene can be accelerated by supplementing with glutathione and N-acetyl cysteine (NAC).

    2-Hydroxyisobutyric Acid (2HIB)
    2-Hydroxyisobutyric acid is formed endogenously as a product of branched-chain amino acid degradation and ketogenesis. This compound is also the major metabolite of gasoline octane enhancers such as MTBE and ETBE. Elevated levels indicate environmental exposure and very high values have been reported in genetic disorders.

    Monoethyl Phthalate (MEP)
    MEP from diethyl phthalate is the most abundant phthalate metabolite found in urine. Diethyl phthalate is used in plastic products. Elevated values indicate exposure from various possible sources. Elimination of phthalates may be accelerated by sauna treatment.

    Dimethylphosphate (DMP) & Diethylphosphate (DEP)
    DMP and DEP are major metabolites of many organophosphate pesticides. Reduce exposure by eating organic foods and avoiding use of pesticides in your home or garden. Living near agricultural areas or golf courses and areas regularly sprayed with pesticides will increase exposure. Elimination of organophosphates can be accelerated by sauna treatment.

    3-Phenoxybenzoic Acid (3PBA)
    3-Phenoxybenzoic acid is a metabolite of pyrethroid insecticides. Elimination can be accelerated by sauna treatment.

    2,4-Dichlorophenoxyacetic Acid (2,4-D)
    2,4-D was an ingredient in Agent Orange, and is most commonly used in agriculture of genetically modified foods, and as a weed killer for lawns. Reduce exposure by eating organic foods and avoiding use of pesticides in your home or garden.

    Tiglylglycine (TG)
    TG is a marker for mitochondrial dysfunction. Mutations of mitochondria DNA may result from exposure to toxic chemicals, infections, inflammation, and nutritional deficiencies.

    NAE is a metabolite of acrylamide, which is detoxified through a two-step process. First acrylamide is metabolized by the cytochrome P450s. Second it is conjugated to glutathione in order to make it more water soluble. Acrylamide is used in many industrial processes such as plastics, food packaging, cosmetics, nail polish, dyes, and treatment of drinking water. High levels of acrylamide can elevate a patient’s risk of cancer and cause neurological damage. Supplementation with glutathione can assist in the elimination of this compound.

    Diphenyl Phosphate
    This is a metabolite of the organophosphate flame retardant triphenyl phosphate (TPHP), which is used in plastics, electronic equipment, nail polish, and resins. TPHP can cause endocrine disruption. Studies have also linked TPHP to reproductive and developmental problems.

    Perchlorate is used in the production of rocket fuel, missiles, fireworks, flares, explosives, fertilizers, and bleach. Studies show that perchlorate is often found to contaminate water supplies and food sources. It can disrupt the thyroid’s ability to produce hormones. The EPA has also labeled perchlorate a likely human carcinogen. Patients that are high in perchlorate can use a reverse osmosis water treatment system to remove perchlorate.

    N-Acetyl (3,4-Dihydroxybutyl) Cysteine (NABD)
    NADB is a metabolite of 1,3 butadiene, which is evident of exposure to synthetic rubber such as tires. 1,3 butadiene is a known carcinogen and has been linked to increased risk of cardiovascular disease. Individuals that come into contact with rubber, such as car tires, could absorb 1,3 butadiene through the skin.

    N-Acetyl (2,Hydroxypropl) Cysteine (NAHP)
    NAHP is a metabolite of propylene oxide which is used in the production of plastics and as a fumigant. It is also used in the preparation of lubricants, surfactants, and oil demulsifiers and as a food additive, an herbicide, a microbicide, an insecticide, a fungicide, and a miticide. Propylene oxide is a probable human carcinogen.

    N-Acetyl (Propyl) Cysteine (NAPR)
    NAPR is a metabolite of 1-bromopropane. Chronic exposure can lead to decreased cognitive function and impairment of the central nervous system. Acute exposure can lead to headaches.

    2-Hydroxyethyl Mercapturic Acid (HEMA)
    HEMA is a metabolite of ethylene oxide, which is used in the production of agrochemicals, detergents, pharmaceuticals, and personal care products. Chronic exposure to ethylene oxide has been determined to be mutagenic to humans. HEMA is also a metabolite of vinyl chloride and halopropane, which are used in many commercial chemical processes such as foam glueing, dry cleaning, and in the production of solvents. Supplementation with glutathione should assist in the detoxification process of these chemicals.

    N-Acetyl (2-Cyanoethyl) Cysteine (NACE)
    NACE is a metabolite of acrylonitrile, which is used in the production of acrylic fibers, resins, and rubber. Acrylonitrile is metabolized by the cytochrome P450s and then conjugated to glutathione. Supplementation with glutathione should assist in the detoxification of acrylonitrile.

    Recommendations for Detoxification of Chemicals:
    If you or a patient has had a GPL-TOX profile and/or a Glyphosate test run and found moderate-high levels of any compounds, there are things you can do to help your body eliminate the toxins and to prevent future exposures. The first steps to reducing the amount of toxins presently in the body are to switch to eating only organic food and drinking water that has common toxins, including pesticides filtered out. Most conventional food crops are exposed to larger and larger doses of pesticides and herbicides, and by switching to organic you will prevent exposure to hundreds of these toxicants. Many of these chemicals have also contaminated our water supplies. Installing a high-quality water filtration system in the home that eliminates them is important to do and there are several options available.

    The next step to avoiding future exposures is to change the products you use on a daily basis – from food and beverage containers to beauty and cleaning products. Instead of using plastic water bottles and food containers, switch to glass or metal. Never microwave food in plastic or styrofoam containers and do not drink hot beverages from plastic or styrofoam cups. Make sure your shampoo, soaps, lotions, and other beauty products are free of phthalates. Use cleaning products made from natural ingredients or make your own at home.

    To eliminate toxins from the body, we highly recommend exercise and the use of saunas, especially infrared sauna therapy to rid many chemicals through sweat. Infrared sauna is superior to conventional sauna because it reaches deeper into the body, increasing the circulation in the blood vessels, and causing the body to start to releasing many of the chemicals stored in body fat.

    There are two supplements that are particularly useful in helping the body detoxify. The first is glutathione, or its precursor N-acetyl cysteine. Glutathione is one of the most common molecules used by the body to eliminate toxic chemicals. If you are constantly exposed to toxicants your stores of glutathione could be depleted. The second supplement is vitamin B3 (niacin). Some may not enjoy the flushing that can happen when taking niacin, however, this flushing is from the blood vessels dilating, which is useful in the detoxification process. If sensitive to the flushing, start with the lowest recommended dose and work up from there.

    Test code: 
    GPL-TOX: Toxic Non-Metal Chemical Profile General
  • IgG Food Allergy Test with Candida

    IgG (immunoglobulin G) testing is a useful guide for structuring elimination diets in many chronic conditions. Individuals with neurological, gastrointestinal, and movement disorders often suffer from IgG food allergies. These people may continue to eat offending foods unaware of their potential effects. IgG antibodies provide long term resistance to infections and have a much longer half life than the traditional IgE allergy. Symptoms may occur hours or days after the offending food has been eaten. The 93 foods tested in the IgG Food Allergy Test w/ Candida can identify problem food so it can be eliminated from the patient’s diet. This elimination of IgG positive foods can improve symptoms of irritable bowel syndrome, autism, AD(H)D, cystic fibrosis, rheumatoid arthritis, and epilepsy according to numerous clinical studies.

    The Great Plains Laboratory, Inc. has added Candida to the IgG Food Allergy Test. Candida problems are caused when the benign yeast form of Candida albicans mutates to its fungal form. Candida can take over sections of the intestinal wall causing numerous symptoms. As it grows out of balance it produces toxins that create holes in the intestinal lining, leading to leaky gut syndrome. After entering the blood, Candida albicans causes an inflammatory immune system response. A wide range of disorders have been linked to Candida including autism, multiple sclerosis, depression, and chronic fatigue. Use of antibiotics, oral contraceptives, chemotherapy, and anti-inflammatory steroids greatly increase susceptibility to Candida.

    The Benefits of Testing
    • Helps determine if food reactions are contributing to physical or mental symptoms
    • Removal of highly reactive foods from the diet is a non-invasive, food-based therapy that often mitigates a patient's symptoms
    • Research and clinical studies suggest food allergies identified by IgG testing can be a major contributing factor in many chronic health conditions
    • Food rotation and elimination diets can reduce stress on the immune system, lower gut inflammation, resolve food cravings, and reduce the potential for eating disorders

    Candida albicans Scale in IgG Food Allergy Test

    The Candida albicans scale has been updated to account for the observation that Candida-specific immunoglobulins are present in the specimens of virtually all individuals tested. The new scale is intended to provide a clearer indication of clinical significance and was established according to population percentile ranks obtained from a random subset of 1,000 patients. Specifically, the range of insignificant and low IgG values correspond to the first and second quartiles of the distribution, while moderate values denote individuals in the 51st to 97.5th percentiles. Those with an IgG value greater than the 97.5th percentile are considered to have a high concentration of Candida-specific immunoglobulins.

    IgG Candida Scale
    • 0-25th percentile: Insignificant
    • 26th-50th percentile: Low
    • 51st-97.5th percentile: Moderate
    • 97.5th and higher: High

    Dried Blood Spot (DBS) Collection - The IgG Food Allergy Test w/ Candida is available as a dried blood spot collection. 

    Specimen Requirements: The IgG Food Allergy Test is available thru Dried Blood Spot collection.

    Dried Blood Spot (DBS): Five full circles of dried blood on the protein saver card is required.
    Please note that the elimination of a food prior to sampling will reduce the ability for our laboratory to detect antibodies (allergies) to that food.

    View Sample Report
    Test code: 
    IgG Food Allergy Test with Candida
  • Kryptopyrrole Test - Urine

    Kryptopyrrole - When high levels of kryptopyrrole circulate in the body, it binds with Vitamin B6 and zinc causing them to be depleted faster and preventing their use in the brain and body. A high incidence of this is demonstrated in autism spectrum disorders, AD(H)D, bi-polar disorder, schizophrenia, alcoholism and down syndrome.

    Specimen Requirements

    10 mL of urine collected and poured into an amber vial with ascorbic acid preservative. This test is available in the US only.

    Test code: 
  • Metals Hair Analysis

    Heavy metals toxicity caused by increasing levels of pollution and use of chemicals in industry is a growing threat to our health and development of our children. High levels of toxic metals deposited in body tissues and subsequently in the brain, may cause significant developmental and neurological damage.

    A Metals Hair Test is ideal for checking current exposure to toxic metals. Hair provides important information that can assist the practitioner with an early diagnosis of physiological disorders associated with aberrations in essential and toxic element metabolism.

    Why Choose Metals Hair Test?

    Extensive research established that scalp hair element levels are related to human systemic levels. The strength of this relationship varies for specific elements, and many researchers consider hair as the tissue of choice for toxic and several nutrient elements. Unlike blood, hair element levels are not regulated by homeostatic mechanisms. Thus, deviations in hair element levels often appear prior to overt symptoms and can thereby be a valuable preliminary tool for predicting the development of physiological abnormalities. 

    Hair element analysis provides important information which, in conjunction with symptoms and other laboratory values, can assist the physician with an early diagnosis of physiological disorders associated with aberrations in essential and toxic element metabolism.

    As protein is synthesized in the hair follicle, elements are incorporated permanently into the hair with no further exchange with other tissues. Scalp hair is easy to sample, and because it grows an average of one to two cm per month, it contains a “temporal record” of element metabolism and exposure to toxic elements.

    Nutrient elements including magnesium, chromium, zinc, copper and selenium are obligatory co-factors for hundreds of important enzymes and also are essential for the normal functions of vitamins. The levels of these elements in hair are correlated with levels in organs and other tissues.

    Toxic elements may be 200-300 times more highly concentrated in hair than in blood or urine. Therefore, hair is the tissue of choice for detection of recent exposure to elements such as arsenic, aluminum, cadmium, lead, antimony, and mercury. The CDC acknowledges the value of hair mercury levels as a maternal and infant marker for exposure to neurotoxic methylmercury from fish.

    Through recent vast improvements in technology, instrumentation, and application of scientific protocols, hair element analysis has become a valuable tool in providing dependable and useful data for physicians and their patients. The U.S. Environmental Protection agency stated in a recent report that “...if hair samples are properly collected and cleaned, and analyzed by the best analytic methods, using standards and blanks as required, in a clean and reliable laboratory by experienced personnel, the data are reliable.” (U.S.E.P.A. 600/4-79-049)

    Hair element analysis is a valuable and inexpensive screen for physiological excess, deficiency or maldistribution of elements. It should not be considered a stand-alone diagnostic test for essential element function, and should be used in conjunction with patient symptoms and other laboratory tests.

    The Benefits of Metals Testing
    • Determine if metal toxicity or mineral deficiency is contributing to the disorder
    • Monitor the effects of chelation (elimination of heavy metals from the body)
    • Identify if supplementation of important minerals may bring about significant improvements
    Specimen Requirements

    0.25 grams (approximately 1 tablespoon) of hair is the absolute minimum. 1 gram is preferred.

    Test code: 
    Metals Hair Analysis
  • Mold & Mycotoxin - MycoTox Profile - Great Plains Laboratory



    Aflatoxin M1 (AFM1) is the main metabolite of aflatoxin B1, which is a mycotoxin produced by the mold species Aspergillus. Aflatoxins are some of the most carcinogenic substances in the environment.  Aflatoxin susceptibility is dependent on multiple different factors such as age, sex, and diet.  Aflatoxin can be found in beans, corn, rice, tree nuts, wheat, milk, eggs, and meat.  In cases of lung aspergilloma, aflatoxin has been found in human tissue specimens. Aflatoxin can cause liver damage, cancer, mental impairment, abdominal pain, hemorrhaging, coma, and death.  Aflatoxin has been shown to inhibit leucocyte proliferation.  Clinical signs of aflatoxicosis are non-pruritic macular rash, headache, gastrointestinal dysfunction (often extreme), lower extremity edema, anemia, and jaundice.  The toxicity of Aflatoxin is increased in the presence of Ochratoxin and Zearalenone.


    Ochratoxin A (OTA) is a nephrotoxic, immunotoxic, and carcinogenic mycotoxin.  This chemical is produced by molds in the Aspergillus and Penicillium families.  Exposure is primarily through contaminated foods such as cereals, grape juices, dairy, spices, wine, dried vine fruit, and coffee.  Exposure to OTA can also come from inhalation exposure in water-damaged buildings.  OTA can lead to kidney disease and adverse neurological effects.  Studies have shown that OTA can cause significant oxidative damage to multiple brain regions and the kidneys.  Dopamine levels in the brain of mice have been shown to be decreased after exposure to OTA.


    Sterigmatocystin (STG) is a mycotoxin that is closely related to aflatoxin.  STG is produced from several species of mold such as Aspergillus, Penicillium, and Bipolaris. It is considered to be carcinogenic, particularly in the cells of the GI tract and liver.  STG has been found in the dust from damp carpets.  It is also a contaminant of many foods including grains, corn, bread, cheese, spices, coffee beans, soybeans, pistachio nuts, and animal feed. In cases of lung aspergilloma, STG has been found in human tissue specimens.  The toxicity of STG affects the liver, kidneys, and immune system.  Tumors have been found in the lungs of rodents that were exposed to STG.  Oxidative stress becomes measurably elevated during STG exposure, which causes a depletion of antioxidants such as glutathione, particularly in the liver.


    Roridin E is a macrocyclic trichothecene produced by the mold species Fusarium, Myrothecium, and Stachybotrys (i.e. black mold).  Trichothecenes are frequently found in buildings with water damage but can also be found in contaminated grain.  This is a very toxic compound, which inhibits protein biosynthesis by preventing peptidyl transferase activity. Trichothecenes are considered extremely toxic and have been used as biological warfare agents.  Even low levels of exposure to macrocyclic trichothecenes can cause severe neurological damage, immunosuppression, endocrine disruption, cardiovascular problems, and gastrointestinal distress.


    Verrucarin A (VRA) is a macrocyclic trichothecene mycotoxin produced from Stachybotrys, Fusarium, and Myrothecium. Trichothecenes are frequently found in buildings with water damage but can also be found in contaminated grain. VRA is a small, amphipathic molecule that can move passively across cell membranes.  The primary tissues affected by VRA are intestinal and gastric mucosa, bone marrow, and spleen.  VRA causes damage to human cells by inhibiting protein and DNA synthesis, disrupting mitochondrial functions, and by producing oxidative stress (due to generation of free radicals).  Exposure to VRA can cause immunological problems, vomiting, skin dermatitis, and hemorrhagic lesions.


    Enniatin B1 is a fungal metabolite categorized as cyclohexa depsipeptides toxin produced by the fungus Fusarium. This strain of fungus is one of the most common cereal contaminants.  Grains in many different countries have recently been contaminated with high levels of enniatin.  The toxic effects of enniatin are caused by the inhibition of the acyl-CoA cholesterol acyltransferase, depolarization of mitochondria, and inhibition of osteoclastic bone resorption.  Enniatin has antibiotic properties and chronic exposure may lead to weight loss, fatigue, and liver disease. 


    Zearalenone (ZEA) is a mycotoxin that is produced by the mold species Fusarium, and has been shown to be hepatotoxic,  haematotoxic, immunotoxic, and genotoxic.  ZEA is commonly found in several foods in the US, Europe, Asia, and Africa including wheat, barley, rice, and maize.  ZEA has estrogenic activity and exposure to ZEA can lead to reproductive changes.  ZEA’s estrogenic activity is higher than that of other non-steroidal isoflavones (compounds that have estrogen-like effects) such as soy and clover.  ZEA exposure can result in thymus atrophy and alter spleen lymphocyte production as well as impaired lymphocyte immune response, which leads to patients being susceptible to disease. 


    Aspergillus is the most prevalent mold group in the environment.  It has caused billions of dollars of in damage to crops and livestock.  Two of the most common Aspergillus mycotoxins are aflatoxin and ochratoxin.  The main target of these toxins is the liver.  These toxins have been found in all major cereal crops including peanuts, corn, cotton, millet, rice, sorghum, sunflower seeds, wheat, and a variety of spices.  Theyare also found in eggs, milk, and meat from animals fed contaminated grains.  Diseases caused by Aspergillus are called aspergillosis.  The most common route of infection is through the respiratory system.  Aspergillus can cause severe asthma when the mold colonizes the lung, forming a granulomatous disease.


    There are over 200 species of Penicillium that have been discovered.  Penicillium chrysogenum is the most common of these species.  It is often found in indoor environments and is responsible for many allergic reactions.  Penicillium is also a known contaminant in many different food items.  Many different types of citrus fruits can become contaminated with Penicillium, but it can also contaminate seeds and grains.  One reason that Penicillium is such a common infestation is because of its ability to thrive in low humidity.  In the home, Penicillium can be found in wallpaper, carpet, furniture, and fiberglass insulation.  The most common mycotoxin produced by Penicillium is ochratoxin (OTA).  Ochratoxin is nephrotoxic, which means that it damages the kidneys.  It is also carcinogenic.


    Stachybotrys is a greenish-black mold.  This mold can grow on materials with high cellulose and low nitrogen content such as gypsum board, paper, fiberboard, and ceiling tiles.  Stachybotrys is known for its production of the highly toxic macrocyclic trichothecene mycotoxins.  Two of the more common mycotoxins produced by Stachybotrys are roridin E and verrucarin.  In addition to these mycotoxins, the fungus produces nine phenylspirodrimanes, as well as cyclosporine, which are potent immunosuppressors. These immunosupressors along with the mycotoxin trichothecenes may be responsible for the high toxicity of Stachybotrys.


    Fusarium’s major mycotoxins are zearalenone (ZEN) and fumonisin.  Fusarium fungi grow best in temperate climate conditions.  They require lower temperatures for growth than Aspergillus. Fusarium grows worldwide on many different types of grains including corn and wheat.  Exposure to mycotoxins from Fusarium can lead to both acute and chronic effects.  These symptoms can include abdominal distress, malaise, diarrhea, emesis, and death.  ZEN possesses estrogenic effects and has been implicated in reproductive disorders.

    Urine: 5 mL of the first morning urine before food or drink is suggested.  Fasting for 12 hours may increase the excretion of mycotoxins from the adipose tissue.  However, fasting is not recommended if running this test in combination with other urine tests.

    Test code: 
  • Organic Acids Test - Nutritional & Metabolic Profile

    Organic Acids Test (OAT) - Nutritional & Metabolic Profile

    The Organic Acids Test (OAT) provides an accurate evaluation of intestinal yeast and bacteria. Abnormally high levels of these microorganisms can cause or worsen behavior disorders, hyperactivity, movement disorders, fatigue and immune function. Many people with chronic illnesses and neurological disorders often excrete several abnormal organic acids. The cause of these high levels could include: oral antibiotic use, high sugar diets, immune deficiencies, and genetic factors.

    If abnormalities are detected using the OAT, treatments can include supplements, such as vitamins and antioxidants, or dietary modification. Upon treatment, patients and practitioners have reported significant improvement such as decreased fatigue, regular bowel function, increased energy and alertness, increased concentration, improved verbal skills, less hyperactivity, and decreased abdominal pain. The OAT is strongly recommended as the initial screening test.

    View A Sample Report

    Specimen Requirements

    10 mL of first morning urine before food or drink is suggested. Patient should avoid apples, grapes (including raisins), pears, cranberries and their juices 24 hours prior to specimen collection.
    Test code: 
    Organic Acids Test (OAT) - Nutritional & Metab
  • Porphyrins Profile

    Porphyrins are generated as the body builds hemoglobin, the compound that carries oxygen in blood cells. Porphyrin (from the Greek word for purple) is made up of four ring compounds joined together, a structure conducive to holding a metal ion in its center,  iron in the heme porphyrin of hemoglobin and magnesium in chlorophyll. Small amounts of several porphyrins appear in urine normally. The relative amounts of each porphyrin are altered by certain hereditary diseases and by environmental or nutritional influences. The classic cases of hereditary porphyria displayed highly colored urine and skin eruptions and neurological symptoms of mania and “madness.”

    Doubts About The Use Of Porphyrins Testing For Heavy Metals Assessment

    Analyte List

    1. Coproporphyrin I and III (CP)
    2. Heptacarboxy (7-CP)
    3. Hexacarboxy (6-CP)
    4. Pentacarboxy (5-CP)
    5. Precoproporphyrin (PreCP)
    6. Uroporphyrins (UP)
    Specimen Requirements

    10 mL of urine collected and poured into an amber vial with no additive.

    Urine Collection Instructions

    Test code: 
    Porphyrins Profile (MMX0060)
  • RealTime Mold Testing

    Mold & Mycotoxin Testing  

    Testing for mold/mycotoxins in humans is a simple and usually noninvasive procedure. The RealTime Lab mycotoxin test detects 15 different mycotoxins, including 9 macrocyclic trichothecenes. 

    There are estimated to be over 50,000 different species of mold, but only about 200 present serious health risks to humans or animals. These harmful species are referred to as toxic mold and are potentially hazardous because they can produce toxins known as mycotoxins. And their impact can be life threatening.

    Mycotoxin Tests are performed for Tricothecenes, Ochratoxins, Aflatoxins and Gliotoxin. Anyone in contact with mold exposure or with prolonged symptoms of exposure should consider being tested for mycotoxins.

    The RealTime Labs mycotoxin test detects 15 different mycotoxins, including 9 macrocyclic trichothecenes. Testing is done using competitive ELISA, a very sensitive detection method using antibodies prepared against mycotoxins. In fact, RealTime Labs was recently granted a U.S. patent for its macrocyclic trichothecene test.

    This RealTime lab test looks for these specific Molds & Mycotoxins:

    • Ochratoxin A is evaluated using ImmunoSorbant Columns containing antibodies to the Ochratoxin A. Results are reported as PRESENT or NOT PRESENT.
    • Ochratoxins A
    • Tricothecenes are evaluated by using Enzyme-Linked ImmunoSorbant Assay (ELISA). The test at RTL has been validated as a qualitative test. Thus, RTL reports whether tricothecenes are PRESENT or NOT PRESENT.
    • Satratoxin G
    • Satratoxin H
    • Isosatratoxin F
    • Roridin A
    • Roridin E
    • Roridin H
    • Roridin L-2
    • Verrucarin A
    • Verrucarin J
    • Aflatoxins are evaluated using ImmunoSorbant Columns containing antibodies to the group of aflatoxins (B1, B2, G1, and G2). Results are reported as PRESENT or NOT PRESENT. 
    • Aflatoxin B1
    • Aflatoxin B2
    • Aflatoxin G1
    • Aflatoxin G2
    • Glitoxin is a mycotoxin produced by Aspergillus fumigatus, a major cause of death in immunocompromised patients. Gliotoxin has been demonstrated to have significant immunosuppressive effects and may play a role in teh evasion of host defenses in Invasive Aspergillosis.
    All mycotoxin testing results are displayed in an easy-to-understand numeric format, showing detection levels in ppb as standardized by the FDA, WHO, CDC and Food Industry for clinical use. Results also tell if the test was positive, negative or equivocal, along with ranges of detection for each. 
    The health affects of mold and mycotoxin exposure are numerous. Mold  

    Test Preparation For Optimal Results & Test Kit Instructions: 
    • No fasting required. Test sample is a urine sample. 
    • Processing time after the test kit is received is approximately 10-14 Business Days. MyLabsForLife will send you a copy of your test results after they have posted.
    • Kits, with collection instructions, will be sent by UPS within 24 hours of receipt of payment to MyLabsForLife.com.  Depending on your location, UPS delivery can be 1-6 business days (1-4 business days in 80% of the U.S.). The kit is returned to RealTime Labs in the prepaid, 2-day ground UPS shipper that comes with the kit. For test kit information, please contact the support staff at Real Time Labs: 1-855-692-6767.
    • Please note: This test is not available in these states at this time: NY, NJ & RI

    Test code: 
    RealTime Labs Mold and Mycotoxin